PRK vs LASEK vs Epi-LASIK: A comparison of corneal haze, postoperative pain and visual recovery in moderate to high myopia.
Nepal J Ophthalmol. 2010 Jul;2(4):97-104. doi: 10.3126/Nepal Ophthalmic Society.v2i2.3715.
Reilly CD, Panday V, Lazos V, Mittelstaedt BR.
SourceWilford Hall, Warfighter Refractive Surgery Center, San Antonio, TX, USA.

Introduction: The field of refractive surgery continues to evolve amid continued concerns as to which surgical technique minimizes the risk of inducing ectasia. Purpose: To compare clinical outcomes between PRK, LASEK and Epi-LASIK in moderately to highly myopic eyes (-4.00 D to -8.00 D). Materials and methods: A retrospective chart review of 100 PRK eyes, 100 LASEK eyes (with alcohol) and 97 Epi-LASIK eyes was performed. Post-operative pain, uncorrected visual acuity, and corneal haze data was recorded and analyzed at post-op days 1, 4 and 7 and at post-op months 1, 3, 6 and 12. Results: In all groups surgical corrections ranged from -4.00 D to -8.00 D. There was less pain associated with the epi-LASIK procedure especially early (post-op days 1 and 4). Visual recovery was superior within the PRK group during the first post-operative week but by post-op week 4 all three were equal. Haze scores were similar but a trend for less haze was demonstrated with epi-LASIK at 6 and 12 months. Conclusion: Epi-LASIK has a slight advantage over PRK and LASEK early on in the post-op course with regards to pain. Visual recovery is similar by 4 weeks and is better with PRK early. In addition, epi-LASIK trends toward less significant haze.

　　这份临床对比研究于2010年7月发表于尼泊尔眼科杂志。回顾分析了100只PRK手术眼，100只LASEK手术眼和97只Epi-LASIK手术眼术后疼痛，裸眼视力，角膜haze情况，治疗的度数在-400度到-800度之间，观察时间为术后1天，4天，7天，术后1月，2月，6月，12月。结果显示Epi-LASIK术后疼痛最轻，视力恢复情况三者差不多，Epi-LASIK术后haze更轻微。

                                                                       （黄正 译）